Description
FOXO4-DRI is a senolytic peptide — a compound that selectively eliminates senescent cells. Senescent cells are cells that have stopped dividing but refuse to die. They accumulate with age and release a toxic mix of inflammatory signals (called SASP — senescence-associated secretory phenotype) that damages surrounding healthy tissue. These are the “zombie cells” that longevity researchers increasingly see as a root cause of aging.
FOXO4-DRI is not a daily peptide. This is critical, and it’s probably the most common misunderstanding among new users. It’s used in short, infrequent courses — typically a 3-day protocol at a time, repeated quarterly or less frequently. Using it daily would be both unnecessary and counterproductive.
Standard Protocol:
Dose: 1–2mg per injection
Frequency: Once daily for 3 consecutive days
Then stop and wait (months before repeating)
Repeat Frequency:
Most users: 2–4x per year maximum
Some protocols: once per year (3-day course, higher dose)
The reasoning: you don’t want to clear too many senescent cells at once (see side effects), and you don’t need to — the body accumulates them slowly, so infrequent clearance matches the accumulation rate
